NOS inhibitors exhibit antinociceptive properties in the rat formalin test
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منابع مشابه
d-Methadone is antinociceptive in the rat formalin test.
The l-isomer of methadone possesses opioid activity, whereas the d-isomer is weak or inactive as an opioid. Both d- and l-methadone have been shown to bind to the N-methyl-D-aspartate (NMDA) receptor. To determine whether d-methadone has functional, in vivo NMDA receptor antagonist activity, the antinociceptive effects of d-methadone were evaluated in the rat tail-flick and formalin tests. Cumu...
متن کاملParticipation of KATP Channels in the Antinociceptive Effect of Pregabalin in Rat Formalin Test
BACKGROUND Pregabalin is an anticonvulsant and analgesic agent that interacts selectively with the voltage-sensitive-Ca(2+)-channel alpha-2-delta subunit. The aim of this study was to evaluate whether the analgesic action of intrathecal (IT) pregabalin is associated with K(ATP) channels in the rat formalin test. METHODS IT PE-10 catheters were implanted in male Sprague-Dawley rats (250-300 g)...
متن کاملAntinociceptive Effects of Intraperitoneal and Intrathecal Vitamin E in the Rat Formalin Test
BACKGROUND Vitamin E is widely known to be one of the reactive oxygen species (ROS) scavengers and a drug that can easily be obtained, and it has been shown to attenuate the pain responses induced by various causes in animal pain models. Thus, this experiment was conducted to assess the antinociceptive effects of vitamin E by comparing intraperitoneal and intrathecal injections in rats subjecte...
متن کاملAntinociceptive activity of buprenorphine and lumiracoxib in the rat orofacial formalin test: a combination analysis study.
Combination of two or more analgesics is widely used for the treatment of moderate and severe pain syndromes, allowing usage of lower doses of each compound and thereby limiting side effects; there is currently a large interest in investigating the potential advantages of combinations between opioids and non-steroidal inflammatory drugs (NSAIDs), coxibs in particular. The rat orofacial formalin...
متن کاملSynergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.
BACKGROUND Combination therapy is often used to increase the clinical utility of analgesic agents. The coadministration of two compounds may achieve analgesia at doses lower than those required for either compound alone, leading to enhanced pain relief and reduction of adverse effects. Herein, the authors describe the effect of coadministration of morphine and amitriptyline on cutaneous orofaci...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2003
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03018738